BK infection is an important cause of graft dysfunction and graft loss after renal
transplantation. It has been widely accepted that emergence of BK virus correlates with the
more potent immunosuppressive agents used to lower acute rejection rates. In contrast to
other opportunistic infections after transplantation, for which routine prophylactic agents
are administered, there is no effective agent for the prevention of BK infection. Some data,
however, suggests that quinolone antibiotics such as ciprofloxacin may have activity against
BK virus. This has led us to investigate whether routine, short-term ciprofloxacin
administration post-transplant can lower the incidence of BK infection.
Phase:
Phase 4
Details
Lead Sponsor:
The Methodist Hospital Research Institute The Methodist Hospital System