Ciprofloxacin in Drug-resistant Epilepsy

• Status: Completed
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mazandaran University of Medical Sciences
• Treatments: Ciprofloxacin

Criteria

Inclusion Criteria:

• Drug-resistant epilepsy with frequency of at least 2 seizure/Week

• Acceptance of patients or his/her guardian (Signing informed consent)

Exclusion Criteria:

• Hypersensitivity to ciprofloxacin or other fluoroquinolones

• History of tendon, renal, hepatic or cerebrovascular disease, organ transplantation or myasthenia gravis

• Usage of medications with interaction to ciprofloxacin

• No reliable contraception

• Pregnancy or breastfeeding

• Being under treatment with corticosteroid

• Usage of antibiotics in recent 2 months or need to use it during the study

• Patients who are candidate for epilepsy surgery or other nonmedical treatments

• Change in anti-seizure medications (ASMs) during recent month

• Patients who will need changes in ASMs dose during study