Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient

• Status: Completed
• Trial end date: 2019-06-05
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the effect of Acetaminophen on the main parameters of microcirculation, on the plasmatic levels of free hemoglobin/oxidative stress markers and on the expression of PD1/Pd-L1, in pyrexial septic patient.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Università Politecnica delle Marche
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Patients with sepsis, severe sepsis and septic shock with high body temperature that need administration of Paracetamol and which have previously monitored blood pressure and have a central venous catheter in place.

Exclusion Criteria:

• age < 18 years

• pregnancy

• hemodialysis

• hemolysis of the blood sample

• use of Paracetamol in the previous 12 hours

• conditions that do not allow the possibility of getting a monitoring of sublingual microcirculation (maxillofacial trauma, serious inability to jaw, copious blood loss or secretions from the mouth)