Cisplatin/Etoposide and Concurrent Radiotherapy With or Without Celecoxib in Patients With Unresectable Locally Advanced Non-small Cell Lung Cancer (NSCLC)

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Concurrent chemoradiation (ChRT) is a standard care for unresectable stage III non-small cell lung cancer (NSCLC) patients with good performance status, and cisplatin/etoposide (EP) regimen is one of the most commonly used regimens. However, the prognosis of these patients is still rather poor. It has been demonstrated that Cyclooxygenase (COX)-2 plays an important role in the pathogenesis of lung cancer. Selective (COX)-2 inhibitors can promote chemosensitivity and radiosensitivity of tumor cells in preclinical trials.

This is a single-institution, open-label, randomized phase II trial of celecoxib administered concurrently with cisplatin, etoposide, and radiation therapy in patients with locally advanced NSCLC, to determine the feasibility, activity, and toxicity of this combination on unresectable NSCLC, and further to examine biomarkers to predict response to the treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Academy of Medical Sciences
• Treatments: Celecoxib; Cisplatin; Etoposide; Etoposide phosphate

Criteria

Inclusion Criteria:

• • 18-70 years old, male or female

• Histological or cytological evidence of NSCLC.

• Unresectable Stage III NSCLC.

• Karnofsky score: at least 70.

• Estimated survival: at least 6 months

• Not receiving radiotherapy or combined modality therapy to treat another malignancy.

• No history of active gastric ulcer, active GI bleeding, or renal failure.

• No severe hypertension, cardiac disease, or diabetes mellitus

• Normal blood routine and chemical tests

• Patients or guardian must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

Exclusion Criteria:

• • Other malignancies simultaneously except in situ cervix or non-melanoma skin cancer

• Extensive distant metastases

• Pregnancy or in lactation

• Allergic to Sulfonamides, NSAIDS or Celebrex

• Routine use of NSAIDS such as high dose of Aspirin

• History of cardiovascular diseases including: myocardial infraction, angina, coronary angioplasty, congestive heart failure, stroke, or coronary bypass surgery in the last 6 months.

• Abnormal coagulation or history of deep venous thrombosis, pulmonary embolism, systemic lupus erythematous, family history of protein S or C deficiencies, prior heparin-induced thrombocytopenia, Factor V Leiden deficiencies or high homocysteine levels.