Cisplatin and Everolimus in Treating Patients With Advanced Solid Tumors
Status:
Completed
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing.
Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell
growth. Everolimus may also help cisplatin work better by making tumor cells more sensitive
to the drug. Giving cisplatin together with everolimus may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of everolimus when
given together with cisplatin in treating patients with advanced solid tumors or recurrent or
metastatic solid tumors.