Citicholine-Amantadine Trial in Traumatic Brain Injury

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized study aims at comparing between the effects of amantadine, citcholine and its combinations on arousal and behavioral consequences in early phase of moderate Traumatic Brain injury (TBI).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Amantadine; Cytidine Diphosphate Choline

Criteria

Inclusion Criteria:

• Sustained moderate non-penetrating TBI with GCS of 9-12

Exclusion Criteria:

• Patients with mild (GCS > 12) or severe TBI (GCS < 9)

• Patients suffering from any central nervous system disability prior to the traumatic brain injury

• Major medical problems as; major cardiovascular disease or heart failure, renal insufficiency (creatinine clearance, less than 60 ml per minute), liver impairment,

• Pregnancy,

• More than one seizure in the previous month,

• Prior treatment with amantadine,

• Allergy to the study drugs.