Overview

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Status:
Unknown status
Trial end date:
2020-11-15
Target enrollment:
0
Participant gender:
All
Summary
The French intensive care societies (SRLF and SFAR), in agreement with the European and American societies for enteral and parenteral nutrition, recommend to quickly administer an artificial nutrition to patients admitted to ICU and for which it is expected that they will not be able to eat normally in the three days of admission. Enteral nutrition should be used in priority if the gut is functioning. However, intolerance to enteral nutrition, such as vomiting, regurgitation, increased residual gastric volume, or diarrhea, occurs in 40% of patients hospitalized in ICU receiving enteral nutrition. Intolerance to enteral nutrition leads to the risk of not receiving enough nutrition. Feeding intolerance also exposes to the risk of acute mesenteric ischemia, especially in the most severe patients under catecholamine for shock. Currently, it is not possible to predict intolerance to enteral nutrition in ICU patients. Thus, the diagnosis of intolerance is made a posteriori while enteral nutrition is in progress. Citrullinemia (normal concentration of 20 to 60 μmol / L), could be a good biomarker of the function of enterocytes involved in the absorption of food. The aim of this study is to evaluate the interest of citrullinemia to predict tolerance to enteral nutrition in ICU patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Criteria
Inclusion Criteria:

- 18 years old or older

- patient admited to ICU

- expected hospital stay of at least 3 days

- indication of enteral nutrition.

- presence of an arterial catheter

- signed informed consent

Exclusion Criteria:

- contraindication to enteral nutrition (e.g. non-functional digestive tract, mesenteric
ischemia, occlusion, digestive fistula, active gastrointestinal bleeding)

- pregnancy ;

- chronic renal failure;

- chronic intestinal pathology