Clarithromycin as Adjuvant to Periodontal Debridement

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho
• Collaborator: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
• Treatments: Clarithromycin

Criteria

Inclusion Criteria:

• diagnosis of Generalized Aggressive Periodontitis

• presence of ≥20 teeth

• presence of ≥ 6 sites presenting probing depth (PD) ≥5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them)

• good general health

• <35 years of age

• agree to participate in the study and sign a written consent

Exclusion Criteria:

• pregnant or lactating

• suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease

• received antimicrobials in the previous 6 months

• taking long-term anti-inflammatory drugs

• received a course of periodontal treatment within the last 12 months

• smoked