Clinical Activity of Metformin With High-dose of Dexamethasone in Relapse Multiple Myeloma
Status:
Unknown status
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
This phase II trial study assessing the activity of metformin when given together with high
dose of dexamethasone in treating patients with multiple myeloma (MM) that has relapse or
refractory to previous treatment. High dose of dexamethasone (HDdexa) is used to treat
relapse/refractary patients with myeloma and metformin also demonstrated synergistic activity
with dexamethasone to eradicate MM cells in vitro and in vivo. Metformin hydrochloride, used
for diabetes, may also help kill tumor cells. Giving dexamethasone with metformin may kill
more MM cells and increase the response rate to HDdexa.