Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a fish oil-based lipid emulsion, enriched with ω-3 fatty acids, reduce proinflammatory cytokines and mortality rate in critically ill patients with severe sepsis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Li Shin Hospital

Criteria

Inclusion Criteria:

• Patients admitted to Li Shin Hospital's ICU with a main diagnosis of severe sepsis.

Exclusion Criteria:

• Age of ﹤15 years

• Pregnancy

• Patients treated with immunosuppressive drugs or the equivalent of hydrocortisone more than 300 mg daily

• Plasma triglyceride concentration of more than 400 mg/dl

• Infection with human immunodeficiency virus

• Anticipated rapid fatality from irreversible underlying disease or malignancy

• Severe hemorrhagic disorders

• Acute myocardial infarction

• Recent stroke (within 3 month)

• Suspected or proven pulmonary embolism

• Cirrhotic liver and/or acute hepatitis ( elevation of serum GOT or GPT > 5 times of normal upper limit)

• Chronic renal failure (Cr >3.5 mg/dl upon admission) or end stage of renal diseases

• Allergic reactions against fish or egg proteins.