Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy

• Status: Recruiting
• Trial end date: 2022-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

The role of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in patients undergoing hysterectomy remains scarcely explored. A prospective double-blind, randomised controlled trial investigating the effect of a single-dose of intraoperative methadone in patients scheduled for same day hysterectomy is therefore conducted.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Treatments: Methadone; Morphine

Criteria

Inclusion Criteria:

• Patients scheduled for elective laparoscopic hysterectomy for benign indications

Exclusion Criteria:

• American Society of Anaesthesiologists (ASA) physical status IV or V

• prolonged QT-interval assessed by electrocardiogram (> 440 milliseconds)

• Existing treatment with medications prolonging the QT-interval

• Hysterectomy due to malignancy or acute bleeding disorders

• Allergy to study drugs

• Preoperative daily use of opioids

• Severe respiratory insufficiency

• Heart failure

• Acute alcohol intoxication/delirium tremens

• Increased intracranial pressure

• Acute liver disease

• Acute abdominal pain

• Liver insufficiency

• Kidney insufficiency

• Treatment with rifampicin

• Breastfeeding

• Inability to provide informed consent.