Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection

• Status: Completed
• Trial end date: 2020-11-30
• Target enrollment: 0
• Participant gender: All

Summary

The main objectives of the study are; to determine the efficacy of test drug Crano-cure for the treatment of urinary tract infection, to compare the effectiveness of Polyherbal formulation Crano-cure vs. Standard allopathic. Antibacterial/ antibiotic (Ciprofloxacin 500 mg) in treatment of UTI, to assess the safety of trial drug.

Research literatures have revealed that Tribulus terrestris (Gokhro), Vaccinium macrocarpon (karonda), Cuminum cyminum (Zeera sufaid), Rheum emodi (Revand chini) and Piper cubeba (Kabab chini) are important therapeutic plants. Many pharmacological researches have been done on these plants. For instance, antioxidant, antiseptic, anti-microbial, anti-bacterial, anticancer etc. In the above claims and facts, the study is conducted to formulate and evaluate the polyherbal capsule and to find out the most effective combination having anti-bacterial activity.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Islamia University of Bahawalpur
• Collaborator: Hamdard University
• Treatments: Ciprofloxacin

Criteria

Inclusion Criteria:

• Age 15 to 60 years with symptomatic acute urinary tract infection.

• Willing to participate in the study

• Non-pregnant adult females.

• Clinical signs and symptoms of a UTI (e.g., dysuria, frequency, urgency to urinate, Burning sensations during urination, Hematuria, suprapubic pain) with onset of symptoms < 72 hours prior to study entry.

• One positive pre-treatment clean-catch midstream urine culture within 48 hours of enrollment in the study, defined as > 105 CFU/mL.

• Patients having all socioeconomic classes including lower, middle and higher.

• In-vitro susceptibility testing of the uropathogen to test and control drug.

Exclusion Criteria:

• • Women who are pregnant, nursing, or not using a medically accepted, effective method of birth control. If an antimicrobial agent is to be studied for the treatment of UTI in pregnant women, this proposal should be justified, the risk/benefit expectations explained, and the issue presented to the division.

• Three or more episodes of acute uncomplicated UTI in the past 12 months.

• Patients with evidence of factors predisposing to the development of urinary tract infections, including calculi, stricture, primary renal disease (e.g., polycystic renal disease), or neurogenic bladder.

• Patients with onset of symptoms 96 hours or more prior to entry.

• Patients with a temperature > 1010 F, flank pain, chills, or any other manifestations suggestive of upper urinary tract infection.

• Patients with known or suspected hypersensitivity to the test or control drug.

• Patients who received treatment with other antimicrobials within 48 hours prior to entry.

• Patient suffering in chronic illness Diabetes mellitus, chronic liver diseases