Clinical Evaluation of Smoker Periodontal Subjects After Lactobacillus-reuteri Probiotics and Antibiotics Therapy

• Status: Completed
• Trial end date: 2019-05-06
• Target enrollment: 0
• Participant gender: All

Summary

It is a clinical trial conducted on smokers with chronic periodontitis in which the participants are divided into two groups and one group is provided with antibiotics while the other with probiotics as an adjunct to non-surgical therapy. The participants were assessed for change in probing pocket depths, attachment loss, bleeding on probing, plaque index and gingival index after 1-month and 3-month period.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dow University of Health Sciences
• Treatments: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

• systemically healthy males or females.

• at least 35 years of age with minimal 3 natural teeth in each quadrant excluding 3rd molar.

• previously untreated moderate to severe generalized chronic periodontitis

• were current smokers having ≥10 cigarettes /day.

Exclusion Criteria:

• having periodontal therapy within the past 6 months.

• have undergone antibiotics or long-term NSAIDS therapy within the past 6 months.

• have an allergy to penicillin and metronidazole.

• having either fixed or removable prosthesis.

• pregnant or nursing females.