Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery

• Status: Unknown status
• Trial end date: 2020-02-28
• Target enrollment: 0
• Participant gender: All

Summary

Cardioplegia solutions have been used for myocardial protection in cardiac surgery for decades. Different cardioplegic strategies have been evaluated.

Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. It can be used as a single dose and it is a reasonable tool do decrease cardioplegic interventions. Recent meta-analysis based on 9 retrospective studies has shown that "clinical outcomes of Del Nido cardioplegia are noninferior to the outcomes of conventional cardioplegia in adult cardiac surgery".

To assess the potencial benefits of Del Nido cardioplegia we performed this clinical trial to evaluate superiority of Del Nido cardioplegia compared to cold blood cardioplegia in terms of myocardial protection and clinical-related outcomes. 474 participants will be randomized either into Del Nido cardioplegia protocol or into the cold blood cardioplegia protocol. Perioperative outcomes will be presented.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: JESSICA GARCIA SUAREZ
• Treatments: Cardioplegic Solutions

Criteria

Inclusion Criteria:

• Patients age 18 years or older undergoing adult cardiac surgery.

• Elective surgical procedures requiring cardiopulmonary bypass and myocardial arrest.

Exclusion Criteria:

• Emergency surgery.

• Patients on preoperative inotropic support and/or mechanical circulatory support.

• Patient who refuse to participate in the study.

• Lidocaine allergy.

• Port access mitral valve surgery.