Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia
Status:
Unknown status
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
Aim of this prospective, parallel multi-arm, randomized, clinical trial, was to compare the
clinical outcome of patients Methods.We recruited children who undergone diagnostic
colonoscopy in Umberto I Pediatric Department (Rome, Italy) from 2008 to 2010. Eligibility
criteria were: 1) only demonstration of LNH; 2) no concomitant disease; 3) no treatment
assumed since the clinical onset. Patients were allocated 1:1:1 to dietetic (Group A) vs
mesalamine (Group B) vs no treatment (Group C) for a 8-weeks period. Skin prick tests and
patch test for common foods, and symptoms scoring at baseline and follow up have been
performed by blinded clinicians. Chi-square test for trend was used to compare the frequency
of symptoms score improvement (>1 point) among groups. The association of baseline features
of patients with the clinical response was estimated by frequency analysis.