Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
Status:
NOT_YET_RECRUITING
Trial end date:
2026-03-01
Target enrollment:
Participant gender:
Summary
This prospective, sequential dose-finding clinical observational study aims to estimate the median effective concentration (EC50) and the 95% effective concentration (EC95) of liposomal bupivacaine for ultrasound-guided femoral nerve block. Sensory and motor block endpoints are evaluated separately at 30 minutes after block placement using a modified up-and-down (sequential allocation) design, with trial termination after eight reversal points.
Phase:
PHASE2
Details
Lead Sponsor:
Hainan Medical College
Collaborator:
The Second Affiliated Hospital of Hainan Medical University