Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Anecdotal reports suggest buffering lidocaine with epinephrine just before intraoral injection reduces time of onset, results in a deeper anesthetic effect, without the "sting" with injection from a low pH. Additional data are needed to establish clinical important outcomes such as the peak blood level of lidocaine as compared to the non-buffered drug combination.

Clinical pilot studies are proposed as the start of a series of investigations to support or modify the use of the buffered anesthetic for intraoral procedures.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Collaborator: Dental Foundation of North Carolina, Inc.
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Age 18-30 years

• ASA I

• Willingness to complete QOL instrument

• Willingness to participate in two sessions

Exclusion Criteria:

• Allergy to lidocaine class of anesthetic drugs

• Local anesthetic drug use in past week

• Current symptoms teeth or oral mucosa