Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF)
Status:
Completed
Trial end date:
2024-02-26
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting
Dapagliflozin on the same day of hospital admission in patients with acute decompensated
heart failure (ADHF) with reduced ejection fraction.
The main questions it aims to answer are:
- Does early initiation of Dapagliflozin improve the length of hospital stay and
in-hospital mortality in patients with ADHF?
- Does early initiation of Dapagliflozin enhance the diuretic response, weight reduction
and pro-BNP reduction in the acute stage of HF?
- Does early initiation of Dapagliflozin adversely affect the hemodynamic stability and
kidney functions in the acute stage of HF?
Participants will be randomized with the ratio of 1:1 within 24 hours of admission to receive
Dapagliflozin 10 mg/day versus standard of care. Follow up will continue for 2 months after
hospital discharge.
Researchers will compare the in-hospital and 60-day clinical outcomes in the Dapagliflozin
group versus the standard treatment group.