Overview

Clinical Study Evaluating and Comparing the Safety and the Possible Efficacy of Pentoxifylline in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy

Status:
Recruiting

Trial end date:
2027-11-20

Target enrollment:

Participant gender:

Summary

Epilepsy is a chronic neurological disorder affecting millions of people all over the world. Epileptic seizures are caused by abnormal synchronized electrical neuronal discharges that could be either focal or widespread. Pathogenesis of epilepsy involves multiple processes including genetics, oxidative stress, ion channels, neuroinflammation, and cellular damage through autophagy and apoptosis. Neuroinflammation is considered one of the most important factors contributing critically to epileptogenesis.

Phase:

Phase 2

Details

Lead Sponsor:

Mostafa Bahaa

Collaborators:

Principal Investigator Maha Ahmed Younis, PhD Pharmacy Practice Department- Horus University
Sahar El-Haggar, Prof Clinical pharmacy Department- Tanta University
Tarek Mohamed Mostafa, Prof Clinical pharmacy Department- Tanta University

Treatments:

Pentoxifylline
Phenytoin