Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function

• Status: Unknown status
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Whether use of SNP during cardiac surgery has any effect on thyroid function has not yet been investigated in humans. The aim of this study was to investigate the effects of SNP administration during the rewarming period of cardiac operations on circulating levels of thyroid hormones.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kavaklıdere Umut Hospital
• Collaborator: Ankara University
• Treatments: Nitroprusside

Criteria

Inclusion Criteria:

Patients without history of:

• thyroidal disease

• hypertension

• pulmonary disease

• peripheral vascular disease

• stroke

• recent myocardial infarction within the week prior to operation

• unstable angina pectoris

• liver or kidney dysfunction

• morbid obesity

• cachexia

• sulfonylurea intake

Exclusion Criteria:

• Patients who needed positive inotropic pharmacologic support during or after the operation

• Patients who developed atrial fibrillation in the post operative period requiring amiodarone therapy

• In addition, patients receiving any medication known to interfere with any step of thyroid hormone metabolism such as

• amiodarone

• propranolol

• furosemide

• non-steroidal anti-inflammatory agents

• steroids

• estrogens

• antacids

• diphenylhydantoin

• spironolactone