Overview

Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AML

Status:
RECRUITING
Trial end date:
2029-12-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to estimate the rate (probability) of complete remission or complete remission with incomplete count recovery (CR/CRi) with negative MRD after induction I and II, event-free survival (EFS), and cumulative incidence (probability) of relapse (CIR), in patients receiving molecular/precision medicine and MRD-driven remission inductions, and to assess secondarily if there is an improvement over the AML2018 protocol.
Phase:
PHASE2
Details
Lead Sponsor:
Children's Hospital of Soochow University
Treatments:
avapritinib
Cytarabine
Etoposide
gilteritinib
Homoharringtonine
Idarubicin
Sorafenib
venetoclax