Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura
Status:
Recruiting
Trial end date:
2021-10-30
Target enrollment:
Participant gender:
Summary
IgA vasculitis is relatively common in children,especially in Asian countries. Abdominal
manifestation could be severe, including bleeding, pancreatitis,appendicitis and intestinal
intussusception. Delayed diagnosis could be fatal and cause severe complications.Nowadays no
guidelines for those with severe abdominal manifestations in China.However, the most used
treatment is steroid. For those severe forms are methylprednisolone pulse, IVIG,
immunosuppressants and blood purification. Given the fact that different strategies lead to
different endings which varies in cost, adverse effect and clinical outcomes in different
medical centers, it is necessary to give birth to a useful and feasible strategy. This
clinical trial is a muti-center, randomized,controlled prospective study.Patients with
gastrointestinal disease will be recruited in three children's medical centres in Shanghai
and will be randomized to two groups: MP group and IVIG group. Cost effect and clinical
outcomes will be evaluated. Blood purification will be evaluated as a remedy when MP and IVIG
fail to cure.
Phase:
N/A
Details
Lead Sponsor:
Children's Hospital of Fudan University
Collaborators:
Shanghai Children's Hospital Shanghai Children's Medical Center