Clinical Study to Evaluate the Effects of Disulfiram in Patients With Moderate COVID-19

• Status: Completed
• Trial end date: 2021-09-25
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial evaluates the safety, efficacy, and biomarker levels of FDA-approved drug disulfiram in the treatment of adult subjects hospitalized with moderate COVID-19. Disulfiram may limit the hyperinflammatory response associated with COVID-19 and reduce the risk of progression to severe illness.

Subjects will be screened and randomized to receive either daily administration of oral disulfiram or placebo for 14 days. Subjects will be followed up on Day 28.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ETICA
• Collaborator: Spring Research Foundation
• Treatments: Disulfiram

Criteria

Inclusion Criteria:

Subjects may be enrolled in the study only if all the inclusion criteria are met.

1. Male and female subjects, age 35 or older.

2. Female subjects of childbearing potential must have a negative hCG (in urine or blood) pregnancy test.

3. An International Ethics Committee (IEC) approved informed consent is signed and dated prior to any study-related activities.

4. Willing to abstain from any alcohol or substances containing alcohol (including medications, personal hygiene products, salad dressing) within 24 hours prior to treatment and for 14 days after treatment concludes.

5. Have the ability to understand the requirements of the study and is willing to comply with all study procedures and visits.

6. Respiratory rate: ≤ 30 per minute.

7. Use supplemental O2 via nasal cannula or equivalent.

8. Currently hospitalized ≤ 5 days.

9. PCR test or rapid antigen test confirming SARS-CoV-2.

10. In the opinion of the investigator, able to participate in the study.

Exclusion Criteria:

Subjects may not be enrolled in the study if any of the exclusion criteria apply.

1. Admission into the Intensive Care Unit (ICU) at screening and baseline.

2. Clinically active Hepatitis.

3. ALT or AST > 3 times the upper limit of normal.

4. Need for invasive or non-invasive ventilation at screening and baseline.

5. Stage 4 severe chronic kidney disease or requiring dialysis or estimated GFR < 30.

6. Known allergy to disulfiram.

7. Treatment with any of the medications listed below within 7 days prior to the baseline visit 1: Amprenavir, Dronabinol, Hydantoins, Metronidazole, Ritonavir, Benznidazole, Dyphylline, Idelalisib, Naltrexone, Sertraline, Chloral Hydrate, Ethanol, Immuno-modulatory drugs, Paclitaxel, Tinidazole, Cocaine, Ethotoin, Ixabepilone, Phenytoin, Tipranavir, Cyclosporine, Fosphenytoin, Lithium, Pimozide, Tranylcypromine, Dasabuvir, Guaifenesin, Mesoridazine, Pirfenidone.

8. Participation in any other interventional trial within 30 days prior to enrollment.

9. Active malignancy (excluding basal cell carcinoma, squamous cell carcinoma, in situ cervical cancer, or adenocarcinoma of the prostate with low or very low-risk categories by NCCN criteria).

10. Any surgical or medical condition which in the opinion of the investigator may interfere with participation in the study or which may affect the outcome of the study.

11. Fully vaccinated for COVID-19 (number of doses as per manufacturer recommendation.