Clinical Study to Evaluate the Efficacy and the Safety of Eradication Therapy for Helicobacter Pylori in Functional Dyspepsia

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The role of Helicobacter pylori infection in functional dyspepsia remains controversial. Several randomized controlled trials in western countries have shown no significant advantage over placebo. But some recent studies in Asian population were different compared to the result of studies in the Western population. At the present time, it seems to be difficult to conclude the efficacy of the H.pylori eradication therapy in patients with H. pylori-infected functional dyspepsia.

The investigators hypothesize that eradication of Helicobacter pylori has a sustained global symptom improvement in patients with H. pylori infected functional dyspepsia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korean College of Helicobacter and Upper Gastrointestinal Research
• Treatments: Amoxicillin; Clarithromycin; Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

• Functional dyspepsia by Rome III criteria

• Normal endoscopic findings

• H. pylori positive by Urea breath test

Exclusion Criteria:

• Patients with severe concomitant systemic disease

• Patients with GI surgery

• Females with pregnancy or breast-feeding

• Irritable bowel syndrome, inflammatory bowel disease

• Duodenal Ulcer, Gastric Ulcer, GI bleeding

• History of eradication therapy of Helicobacter pylori

• Malignancy

• Psychosomatic disease