The main purpose of this study is to look at the cancer-free survival at two years of
subjects with high risk upper tract urothelial cancer when treated with the combination of
two chemotherapy drugs called Gemcitabine and Cisplatin followed by surgery to remove the
kidney, all or part of the ureter (ureters are tubes made of smooth muscle fibers that propel
urine from the kidneys to the urinary bladder), and a cuff of bladder where the ureter drains
into the bladder. Other purposes of the study include looking at the safety of Gemcitabine
and Cisplatin before surgery for this type of cancer, time to recurrence of cancer, and
overall survival.
Exploratory integrative tumor sequencing:
The purpose of this part of the study is to test deoxyribonucleic acid (DNA) and ribonucleic
acid (RNA) in various types of samples (tissue and blood) to detect different types of cancer
genetic changes in upper tract urothelial cancer (UTUC) to help develop future studies in
UTUC. DNA and RNA contain key instructions for cell function and help determine the
characteristics of each individual such as hair, eye, and skin color, height, susceptibility
to diseases, and other characteristics.
Phase:
Phase 2
Details
Lead Sponsor:
University of Michigan Cancer Center University of Michigan Rogel Cancer Center