Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

Axillary hyperpigmentation is a frequent consultation in dark skin populations although its exact prevalency is unknown. Currently, there are not studies about physiopathology and treatment for this entity. The objective is to evaluate the depigmenting effect of topical 4% niacinamide versus 0.05% desonide in axillary hyperpigmentation.

At least 30 axillas with hyperpigmentation in individuals of phototype III-V, aged 18-50 years are going to be randomly assigned to receive niacinamide, desonide or placebo daily. No hygienic habits will not be modified. Volunteers will be evaluated at baseline and for 9 weeks, by means of histological, histochemical and immunohistochemistry analysis, as well as Transepidermal Water Loss (TEWL), colorimetry, clinically and by photography control.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidad Autonoma de San Luis Potosí
• Collaborator: Hospital Central "Dr. Ignacio Morones Prieto"
• Treatments: Desonide; Niacin; Niacinamide; Nicotinic Acids

Criteria

Inclusion Criteria:

• Women over 18 years old

• Healthy

• Clinical diagnosis of axillar hyperpigmentation

Exclusion Criteria:

• Pregnancy or lactation

• Obesity

• Endocrinological diseases

• Mental diseases

• Treatment for axillar hyperpigmentation in the last 2 months