Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
This will be a double blind, placebo-controlled study of patients ≥65 years of age undergoing
surgery of the spine, hips and knees replacement at the University of California, San
Francisco (UCSF) Medical Center. Intraoperative anesthetic and postoperative pain management
will be standardized. Patients will be randomized to receive either placebo or gabapentin
preoperatively, and continued postoperatively until discharge. Intraoperative anesthetic and
other postoperative pain management strategies will be standardized. Postoperative delirium
will be measured using structured interviews. Cognitive function will be measured using a
battery of neurocognitive tests pre- and post-operatively. Using an intention to treat
strategy, we, the researchers at UCSF, will compare the incidence of postoperative delirium
and cognitive dysfunction, the amount of postoperative pain, and narcotic requirements
between the two groups. The primary outcome will be postoperative delirium. Secondary
outcomes will be postoperative pain and opioids use, and length of hospital stay, and
cognitive dysfunction.