Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

• Status: Completed
• Trial end date: 2020-04-30
• Target enrollment: 0
• Participant gender: All

Summary

In this clinical study, a total of 1500 patients with out-of-hospital cardiac arrest in Seattle/King County will be enrolled. This will be a randomized clinical trial and patients will receive either two different doses of IV sodium nitrite (45 mg or 60 mg) or placebo during resuscitation in the field by paramedics. The primary outcome will be proportion of patients surviving to hospital admission.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Washington
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)

Criteria

Inclusion Criteria:

• Cardiac arrest, either VF or non-VF, patients receiving ACLS by paramedics

• IV or IO access

• Comatose

Exclusion Criteria:

• traumatic cause of cardiac arrest

• prisoner, pregnancy

• known DNAR