Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function
Status:
Unknown status
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Introduction: Chronic kidney disease is characterized by a progressive deterioration of renal
function. At the end of the progression, when complications occur (overhydration, electrolyte
imbalances or retention of uremic toxins), a percentage of patients requiring renal
replacement therapy (haemodialysis). When starting the haemodialysis, the patient holds the
residual renal function (RRF) which is lost over time. To preserve the RRF, the patient is
treated with diuretics loops and / or thiazide diuretics. The effect of this treatment is
lost when renal function worsens. In this context, there are few studies that explore the use
and effectiveness of diuretics in patients on haemodialysis 2. Objectives and Hypothesis:
Hypothesis: The treatment with furosemide and hydrochlorothiazide in haemodialysis patients
with RRF could:
- To decrease in weight gain between haemodialysis sessions.
- To increase urine volume.
- To decrease the ultrafiltration in haemodialysis sessions ( the long interdialytic
interval)
Main Objective:To asses the effect of combined hydrochlorothiazide-furosemide therapy on gain
weight between haemodialysis sessions in patients with RRF
Secondary Objective: To asses the effect of combined hydrochlorothiazide-furosemide therapy
on dialytic, clinical and analytical variables and use of the antihypertensive treatment
3. Methodology: Randomized open clinical trial to compare the effectiveness of the
administration of diuretics in haemodialysis patients with residual renal function in single
centre.
The population of study are patients with chronic renal disease in haemodialysis therapy that
they preserve residual renal function ( more 200ml daily of urine). It will be a simple
randomization, to asses the effect of combined hydrochlorothiazide-furosemide therapy
After a of 15 days washout without diuretic treatment, patients will be randomized to receive
or not receive combined diuretic treatment for 1 month. After a 1 month washout , the
patients will be receive or not the treatment according to cross over trial.