Clinical Utility of Endothelial Dysfunction in PAD
Status:
Terminated
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
This study will seek to determine whether non-invasive measures of endothelial function have
utility as surrogate markers of cardiovascular risk in patients with peripheral arterial
disease undergoing vascular surgery. Measurements of endothelial function will be made before
and after initiation of atorvastatin, ascorbic acid, or placebo therapy during the
pre-operative period. We will then examine cardiovascular events following surgery. We
hypothesize that patients who have no improvement in endothelial function will have increased
cardiovascular risk compared to patients with improvement in endothelial function.