Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

• Status: Unknown status
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and determine whether the effect, if any, was due to its antioxidant activity.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Coenzyme Q10; Ubiquinone

Criteria

Inclusion Criteria:

1. Patients free from any systemic disease according to the detailed questionnaire of the modified Cornell Medical Index 34.

2. Patients not receiving any medication either topical or systemic that could cause lichenoid reaction during the 3 months before the study.

3. Patients diagnosed by a dermatologist and oral medicine specialist as suffering from OLP.

4. Patients clinically and histopathologically diagnosed as suffering from OLP according to World Health Organization's (WHO's) clinic-pathological diagnostic criteria for LP35.

5. Patients who agree for the biopsy in undiagnosed cases.

6. Patients who are willing to participate in this study (will give informed consent) and have the ability to complete the study.

• Exclusion criteria:

(1) Patients taking systemic drugs such as systemic steroid, other immunosuppressive therapy for at least 8 weeks prior to the study.

(2) Patients treated with any oral topical medications for at least four weeks prior to the study.

(3) Patients with suspected restoration-related reaction. (4) Pregnant and lactating mothers.