Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology
Status:
Recruiting
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
Goal: to to examine the formation of postvaccination immunity and evaluate the therapeutic
effect of bacterial vaccines in patients with inflammation diseases of bronchopulmonary
system. Objectives of the study: assessment of microbiocenosis mucous membranes of the upper
respiratory tract in patients with bronchopulmonary pathology before and after use of
bacterial vaccines. Identification of mayor lymphocytes subpopulations, proinflammatory
cytokines, inflammatory markers in patients in the dynamics of the vaccination process.
Study the profile of humoral immune response in patients under different schemes of
vaccination. Detection of levels of autoantibodies against tissue antigens in the sera of
vaccinated patients with inflammatory diseases of the respiratory tract. Assessment of the
clinic and functional status bronchopulmonary system in the immunized patients. Development
of methodical recommendations / study guides for the improvement of therapy in patients with
different inflammation diseases of the respiratory tract.