Clinical and Metagenomic Investigation of Antimicrobial Peptide Gel in Periodontal Treatment.
Status:
Completed
Trial end date:
2021-04-30
Target enrollment:
Participant gender:
Summary
Background and objective(s): Periodontitis is initiated by a dysbiotic host-microbe
relationship. Standard periodontal treatment involves oral hygiene education, mechanical
debridement and periodic follow-ups with the aims of pocket closure and maintaining a
symbiotic microbial community. Nonetheless, this therapy alone may fail due to the
limitations of mechanical instrumentation. The use of antimicrobial in combination to
subgingival debridement has been proposed for initial and recurrent periodontitis to enhance
the effectiveness of mechanical instrumentation. Antimicrobial peptide (AMP) comprised of a
wide range of peptide, was found naturally in various life forms or manufactured as a
synthetic compound. This study was conducted to evaluate the use of AMP as an adjunct to
non-surgical periodontal treatment in terms of clinical and microbiological outcomes.
Hypothesis
• There are changes in clinical periodontal parameters and subgingival microbial profile
following treatment with locally delivered synthetic AMP.