Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles

• Status: Not yet recruiting
• Trial end date: 2024-03-31
• Target enrollment: 0
• Participant gender: All

Summary

LSTR will be done for primary teeth with significant root resorption needing non-vital pulp therapy to save such teeth for up to 12 months. The first part will be in vitro study to compare the antimicrobial effect of double antibiotic paste mixed with chitosan nanoparticle vs double antibiotic paste mixed with propylene glycol. The second part will be randomized clinical trial comparing the clinical and radiographic success of LSTR in study group where double antibiotic mix is mixed with chitosan nanoparticles and control group where double antibiotic paste is mixed with propylene glycol .

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chitosan

Criteria

Inclusion Criteria:

1-Non-vital primary molars

1. With root resorption more than 1 mm that needs to be retained a tooth for up to 12 months that otherwise would be extracted

2. Without mobility up to grade I mobility.

Exclusion Criteria:

1. Non-vital primary molars

1. With perforation into the bifurcation.

2. Badly broken down.

3. With no root resorption.

4. With excessive bone loss in furcation area involving underlying tooth germ.

5. Nearing exfoliation.

2. Participants that

1. Have previous history of allergy to the antibiotics used in the study.

2. Their caregivers do not oblige to signing the informed consent.