Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is a randomised control trial to assess the visual and clinical outcomes of collagen cross linking in fungal keratitis. Fungal keratitis is a major cause of corneal blindness in India and the therapeutic options available are minimal to handle the advanced complications and sequalae caused by the disease.The antimicrobial and tissue remodeling role of corneal cross linking was demonstrated by several studies earlier,we anted to specifically assess the role of corneal cross linking in non resolving fungal keratitis in prevention of perforation and enhancement of healing process.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aravind Eye Care System
• Treatments: Antifungal Agents; Clotrimazole; Miconazole; Natamycin; Voriconazole

Criteria

Inclusion Criteria:

• Ulcer size more than 5 mm

• Ulcer depth upto 70% of stromal depth

• Corneal thickness of 400 microns and above

Exclusion Criteria:

• Corneal thickness of below 400 microns

• Ulcers involving the limbus

• Pregnant women

• Children below the age of 18 years