Clofarabine, Cytarabine, and G-CSF in Treating Patients With Myelodysplastic Syndromes
Status:
Terminated
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as clofarabine and cytarabine, work in different
ways to stop the growth of cancer cells, either by killing the cells or by stopping them from
dividing. Colony-stimulating factors, such as G-CSF, may increase the number of immune cells
found in bone marrow or in peripheral blood and may help the immune system recover from the
side effects of chemotherapy. Giving clofarabine and cytarabine together with G-CSF may kill
more cancer cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of clofarabine and
to see how well it works when given together with cytarabine and G-CSF in treating patients
with myelodysplastic syndromes.