Clomid in Men With Low Testosterone With and Without Prior Treatment

• Status: Completed
• Trial end date: 2018-10-31
• Target enrollment: 0
• Participant gender: Male

Summary

This study aims to explore whether men with low testosterone levels, due to altered brain regulation of male hormone function, who have been previously treated with testosterone, respond as well as men who have not been so treated to clomiphene citrate, an agent commonly used for female infertility that has been shown to improve male hormone secretion in some cases.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Phoenix VA Health Care System
• Treatments: Citric Acid; Clomiphene; Enclomiphene; Methyltestosterone; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate; Zuclomiphene

Criteria

Inclusion Criteria:

• Patient or eligible for care at Phoenix VA Health Care System

• Male ages 30-70 years

• testosterone level below 250 ng/dl before treatment

• able to provide informed written consent

Exclusion Criteria:

• evidence of pituitary tumor >1mm by MRI or CAT scan

• chronic illness (renal, cardiac, liver failure)

• Prostate specific antigen (PSA) >4.0 ng/ml

• history of prostate, breast, or testicular cancer

• eye disease compromising vision (e.g. cataracts)