Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
The postpartum period represents a stage of the pregnancy-puerperal still rarely addressed
scientifically. There are no reports in the literature and concrete enough to elucidate
important issues, especially in the field of hypertension and pregnancy.
Searches based on current evidence concentrate their focus on the diagnosis of hypertensive
disorders and treatment of these diseases maternofetais repercussions. However, the prognosis
in the short and long term, as the BP outcome in mothers with severe preeclampsia, the most
effective treatment for the control of hypertensive crisis and metabolic and cardiovascular
events after two years of termination of pregnancy require further clarification.
The main idea for developing this research came from the clinical experience with the use of
captopril in Obstetric ICU IMIP. This drug has long been used in postpartum women with severe
preeclampsia or chronic hypertension exacerbated by pregnancy for control of hypertensive
crisis and keeping pressure levels. Following the technical standards of the institution and
during his administration, there were reports of side effects such as dry cough and nausea,
beyond the threshold dose of 150mg daily captopril was easily achieved hindering control the
use of hypotensive.
Alternative therapy, clonidine began to be used in mothers with some restriction on the use
of ACE inhibitors and its hypotensive effect for peak pressure was satisfactory. What is not
known yet is how long clonidine reduces high blood pressure and how long to leave stabilized
compared to the use of captopril.
There are no reports in the literature databases, no randomized clinical trials that prove
the effectiveness of clonidine for the treatment of hypotensive pressure peaks in this
particular group of patients, even in comparison with other classes of antihypertensive
drugs, especially captopril, to this purpose.
The investigators' primary assumption is that clonidine has better effectiveness in
decreasing the frequency of pressure peaks when compared with captopril.
Phase:
Phase 4
Details
Lead Sponsor:
Instituto Materno Infantil Prof. Fernando Figueira