Clonidine-induced Spinal Acetylcholine Release: Normal Volunteers vs. Neuropathic Pain

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the amount of acetylcholine release after a single injection of clonidine in normal volunteers and individuals with neuropathic pain.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wake Forest School of Medicine; Wake Forest University Health Sciences
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Acetylcholine; Adrenergic Agonists; Clonidine

Criteria

Inclusion Criteria:

• Healthy adult volunteers

• Patients with neuropathic pain

Exclusion Criteria:

• Pregnancy

• Allergy to clonidine

• Currently taking clonidine or other direct a2-adrenergic agonists

• Taking cholinesterase inhibitors