Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Regular physical activity is associated with many health benefits for individuals with type 1
diabetes including improved cardiovascular fitness and vascular health, decreased insulin
requirements, improved body composition and quality of life. However, exercise-induced
hypoglycemia is very frequent and thus is the main limiting factor for physical activity
practice in this population.
The artificial pancreas is composed of three components: glucose sensor to read glucose
levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the
required insulin dosages based on the sensor's readings. The artificial pancreas has the
potential to reduce the risk of exercise-induced hypoglycemia but the importance of
announcing exercise to the artificial pancreas is yet to be explored.
The objective of this study is to investigate 1) if announcing postprandial exercise to the
artificial pancreas is beneficial in reducing the risk of hypoglycemia and 2) if an insulin
bolus reduction is necessary when announcing the exercise to the artificial pancreas.