Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
To assess the combined effects of fosamprenavir 700mg BID + ritonavir 100mg BID +
standardized dose of methadone, on plasma total and unbound methadone enantiomer
pharmacokinetics (PK), opiate pharmacodynamic (PD) measures, and safety. The effect of
methadone on plasma amprenavir PK will also be assessed by comparison to historical control
data.