Co-trimoxazole as Maintenance Therapy for Melioidosis
Status:
Completed
Trial end date:
2019-06-21
Target enrollment:
Participant gender:
Summary
This is a randomised, open-labelled, controlled trial to compare the efficacy and
effectiveness on relapse-free rate of 12-week versus 20-week oral eradication treatment of
melioidosis. The study population includes 800 patients with culture-confirmed melioidosis
whom 12 weeks of oral eradication therapy have been completed with or without intravenous
intensive antibiotics. Patients will be randomised to either stop the eradication treatment
or continue current oral treatment for 8 more weeks. The study aim to optimise the regimen
used to treat melioidosis for better compliance and reducing unnecessary use of antibiotics.