Cocaine/Crack and Reduction of Compulsion With Biperiden

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process. Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Collaborators: Association for Psychopharmacological Research, Brazil; Nacional Conseling of Scientific Development and Technology
• Treatments: Biperiden; Biperiden lactate; Cocaine

Criteria

Inclusion Criteria:

• Cocaine or crack dependence, according to the DSM-IV criteria (APA, 1994)

Exclusion Criteria:

• Being under treatment with psychoactive drugs

• Have been diagnosed for other Psychiatric Disorders

• Have dependence diagnosis for other drugs, except for tabacco