Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
Objective of the study was to evaluate the effect of combination of oral Coenzyme Q10
(CoQ10), with clomiphene citrate (CC) for ovulation induction in CC-resistant polycystic
ovary syndrome (PCOS).In a prospective controlled randomized trial performed in a university
hospital and private practice setting. One hundred ten infertile women with PCOS resistant to
CC were randomized to either combined CC/CoQ10 (51 patients, 82 cycles) or CC 150 mg/day
alone (50 patients, 71 cycles) for ovulation induction in patients with CC-resistant PCOS.
Main outcome measures: Number of follicles, serum E2, serum P, endometrial thickness,
pregnancy rate (PR) and miscarriage rate.