Coenzyme q 10 and Fertility Outcome in Women With Clomiphene Resistant PCOS

• Status: Completed
• Trial end date: 2020-10-30
• Target enrollment: 0
• Participant gender: Female

Summary

The study evaluates the effect of coenzyme q 10 on ovulation and subsequent pregnancy in women with polycystic ovarian syndrome. Half of the participants will receive coq10 and ovulation induction with clomiphene and other half would receive a placebo with clomiphene.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karachi Medical and Dental College
• Treatments: Citric Acid; Clomiphene; Coenzyme Q10; Enclomiphene; Sodium Citrate; Ubiquinone; Zuclomiphene

Criteria

Inclusion Criteria:

• Diagnosis of polycystic ovarian syndrome PCOS based on the revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS (2003).

• All women were previously treated with 100 mg of CC daily for 5 days per cycle, for two to three cycles with persistent anovulation or ovulate with very thin endometrium <5 mm at the time of hCG administration

Exclusion Criteria:

• Non-consenting.

• known autoimmune disorders

• prior treatment of endometriosis or surgery to reproductive tract

• prior history of pelvic inflammatory disease

• those with tubal factors and uterine factors as assessed on history and confirmed by normal hysterosalpingogram.

• Thyroid disorder as assessed by history examination and TSH level

• Patients with raised FSH