Overview

Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence

Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
0
Participant gender:
All
Summary
The investigators are conducting a Stage 1 pilot feasibility study at McLean Hospital to develop and refine a Cognitive Behavioral Therapy (CBT) intervention. The investigators aim to develop a feasible 10-week integrated CBT intervention for the treatment of concurrent marijuana dependence and nicotine dependence. The investigators hypothesize that the CBT intervention, in conjunction with Nicotine Replacement Therapy (NRT) in the form of a transdermal nicotine patch, will reduce the use of marijuana and nicotine.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mclean Hospital
Collaborators:
Harvard Medical School
Harvard Medical School (HMS and HSDM)
Treatments:
Nicotine
Criteria
Inclusion Criteria:

- Age range 18-65 years

- current DSM-IV cannabis dependence

- current DSM-IV nicotine dependence

- express a desire to quit cannabis and nicotine use within the next 30 days

- daily use of ≥ 10 tobacco cigarettes

- for women of childbearing age, a negative pregnancy test at screening with agreement
to use adequate contraception to prevent pregnancy and additional pregnancy tests at
weeks 4 and 8

- Expired breath carbon monoxide (CO) determination is greater than or equal to 7 ppm
over ambient values

Exclusion Criteria:

- Current diagnosis of other drug or alcohol dependence (other than cannabis or
nicotine)

- recent (within 3 months) significant cardiac disease

- current serious psychiatric illness or history of psychosis, schizophrenia, bipolar
type I disorder or significant current suicidal or homicidal thoughts

- current use of bupropion

- current NRT or other smoking cessation treatment

- current CBT or other behavioral treatments for cessation of marijuana or tobacco
smoking

- current smokeless tobacco use

- inability to read or write in English