Cognitive Behavioral Therapy for Depression Relapse Prevention in Children and Adolescents

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the effectiveness of cognitive behavioral therapy in preventing a relapse of depressive symptoms in children.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Fluoxetine

Criteria

Inclusion Criteria:

• Diagnosis of nonpsychotic major depressive disorder at least 4 weeks prior to study entry

• Clinical Global Impression severity score of 4 or greater

• Children's Depression Rating Scale score of 40 or greater

• Currently attending school

• Willing and able to use acceptable methods of contraception, if applicable

• In good general health

• Parent or guardian willing to provide informed consent, if applicable

Exclusion Criteria:

• History of psychotic disorders

• Alcohol or substance abuse or dependence within 6 months prior to study entry

• History of anorexia nervosa or bulimia

• Chronic medical illness requiring regular medication

• Current use of medication with psychotropic effects

• First-degree relatives (e.g., mother, father, sister, brother) with bipolar I disorder

• At risk for suicide

• Failure of a previous adequate treatment with fluoxetine (defined as at least 40 mg/day for 4 weeks)

• IQ less than 80

• Pregnancy or breastfeeding