Cognitive Biases Under Ketamine

• Status: Unknown status
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis.

Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is monitored and taken into account for decision making.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre Hospitalier St Anne
• Collaborators: Association Schizo Oui; Comité pour la Recherche Hospitalière Médicale; Fondation Fyssen; Fondation pour la Recherche Médicale
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Right-handed (as assessed by the Edinburgh scale)

• Aged 18 to 39

• Having given an informed consent

• Health insurance

Exclusion Criteria:

• Pregnant or breastfeeding woman (a urine pregnancy test will be offered in doubt)

• Personal or first-degree family history of psychosis

• Personal history of mood disorder, anxiety disorder, obsessive-compulsive disorder, somatoform disorder, dependence on a psychoactive substance, behavior disorder incompatible with a 2 hours EEG recording.

• Psychotropic treatment, current or stopped for less than 1 month, including antidepressant, anxiolytic but excluding hypnotic treatments.

• Personal history of neurologic disorder in relation to the central nervous system :

congenital malformation of the brain, brain tumor, multiple sclerosis, degenerative disease of the central nervous system, epilepsy, current or in remission for less than 3 years or still requiring a medical treatment, inflammatory disease of the central nervous system dating under a year or having resulted in sequelae.

• Known hypertension or blood pressure above 140/90 mmHg upon clinical examination, congenital heart disease, ischemic heart disease, cardiac insufficiency, supraventricular and ventricular heart rhythm disorder.

• Person with restricted liberty, as a result of judicial or administrative measures

• Persons under involuntary commitment as a result of a psychiatric disorder.

• Person subject to a measure of legal protection or unable to consent.

• Known intolerance ketamine.