Cognitive Dysfunction After Cataract Surgery

• Status: Completed
• Trial end date: 2021-04-15
• Target enrollment: 0
• Participant gender: All

Summary

• Cataract surgery is commonly performed in elderly patients who are at high risk for developing postoperative cognitive dysfunction. Most cataract surgeries are performed under peribulbar or retrobulbar anesthesia, however, most of the patients require sedation to relieve the perioperative anxiety and induce amnesia. So, many sedative agents can be used especially benzodiazepines which may increase the risk of developing postoperative cognitive dysfunction.

• Ketamine can be used as a sedative and analgesic agent in a dose of 0.25 -0.5 mg/kg with certain studies suggesting that it may decrease the risk of postoperative cognitive dysfunction. Similarly, dexmedetomidine can be used as a sedative and analgesic agent with the possibility of decreasing the incidence of postoperative cognitive dysfunction.

• this controlled study will compare the effect of ketamine or dexmedetomidine on the POCD of patients undergoing cataract surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Collaborator: Magrabi Hospital - Doha
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Patients aged more than 65 years presented for cataract surgery under peribulbar anesthesia.

Exclusion Criteria:

• Patients with a history of psychological disorders as psychosis, schizophrenia, nephropathy.

• Patients with uncontrolled medical conditions as D.M and hypertension.

• Known allergy to the used medications

• patients with hepatic, renal, or heart failure

• Patients receiving anti-psychotic or anti-depressant medications.