Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment
Status:
Completed
Trial end date:
2016-06-22
Target enrollment:
Participant gender:
Summary
The investigators would like to conduct a double blind placebo-controlled prospective study
to show the impact of a treatment combining a specific cognitive rehabilitation program and
acetylcholinesterase inhibitors on executive function of young patients 3 months after a
first symptomatic stroke. The secondary objectives will be to assess cognitive changes
performance (executive but also non trained functions such as memory) before and after
treatments and treatment effect on activity of daily living and on quality of life.
The main objective of this study is to show the impact of this combined treatment on brain
activation maps in VCI-ND patients in the post-acute phase (3 months) after a stroke.
Treatment effect will be assessed by functional MRI (fMRI) while patients will be performing
a specific executive task.
The investigators hypothesize that the specific rehabilitation associated with
acetylcholinestrase inhibitors treatment will focalize cerebral activation observed in fMRI,
improve executive functions specifically, improve non trained cognitive functions
(generalization effect).